The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could end in an increase in methadone plasma concentrations, which could result in most likely fatal respiratory depression. Furthermore, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally bring about a